Risk of Elective Major Non-Cardiac Surgery After Coronary Stent Insertion: A Population-Based Study
Background—Guidelines recommend that non-cardiac surgery be delayed until 30 to 45 days after bare-metal stent implantation and one-year after drug-eluting stent implantation.
Methods and Results—We used linked registry data and population-based administrative healthcare databases to conduct a cohort study of 8116 patients (≥40 years) who underwent major elective non-cardiac surgery in Ontario, Canada between 2003 and 2009, and received coronary stents within 10 years before surgery. Approximately 34% (n=2725) underwent stent insertion within two years before surgery, of whom 905 (33%) received drug-eluting stents. For comparison, we assembled a separate cohort of 341,350 surgical patients who had not undergone coronary revascularization. The primary outcome was 30-day major adverse cardiac events (mortality, readmission for acute coronary syndrome or repeat coronary revascularization). The overall rate of 30-day events in patients with coronary stents was 2.1% (n=170). When the interval between stent insertion and surgery was less than 45-days, event rates were high for bare-metal (6.7%) and drug-eluting (20.0%) stents. When the interval was 45 to 180 days, the event rate for bare-metal stents was 2.6%, approaching that of intermediate-risk non-revascularized individuals. Adjusted analyses suggested that event rates were increased if this interval exceeded 180 days. For drug-eluting stents, the event rate was 1.2% once the interval exceeded 180 days, approaching that of intermediate-risk non-revascularized individuals.
Conclusions—The earliest optimal time for elective surgery is 46 to 180 days after bare-metal stent implantation or more than 180 days after drug-eluting stent implantation.
- Received February 28, 2012.
- Accepted July 6, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited