Cardiovascular and Metabolic Regulation by the Adiponectin/CTRP Family of Proteins
Cardiovascular disease including ischemic heart disease is the major cause of morbidity and mortality in the developed countries1. Obese states are closely linked with the development of metabolic dysfunction and cardiovascular disorders2,3. It is well-established that adipose tissue secretes various hormonal factors, also known as adipokines, and affects nearby or remote organs in an autocrine, paracrine and endocrine manner3-5. Increasing evidence indicates that dysregulated adipokine production caused by excess fat accumulation contributes to obesity-associated complications4. Most adipokines are up-regulated in obese states, and usually act as pro-inflammatory mediators that promote the disease process4. Conversely, a few adipokines are downregulated by obesity and these factors typically exert beneficial actions on obesity-linked disorders. (SELECT FULL TEXT TO CONTINUE)
- Received May 21, 2012.
- Accepted May 25, 2012.
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