A Bridge Far Enough?
The publication of the ADVANCE trial by Aaronson, Slaughter, and colleagues tracks continuing advance in the rapidly expanding field of mechanical circulatory support1. As implantable device technology and the clinical learning curve have supported better outcomes over time, the journey is leaving the critically ill patients behind and moving into populations with less imminent risk of death, and will soon include more ambulatory patients for whom pivotal outcomes extend beyond stroke-free survival. The success of this trial stimulates questions about routes to new device approval, the length of our bridges, and the directions for travel beyond a bridge. (SELECT FULL TEXT TO CONTINUE)
- Received May 15, 2012.
- Accepted May 16, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited