The Double-Edged Sword of the New Cancer Therapeutics
Protein kinases regulate a vast array of cellular processes including, but not limited to, cell proliferation, differentiation, motility, death, and survival. They regulate these and other processes by attaching phosphate groups onto various proteins (substrates), changing the substrate's activity, sub-cellular localization, resistance to (or promotion of) cell death, etc. There are 500+ kinases in the human genome (referred to as the kinome). (SELECT FULL TEXT TO CONTINUE)
- Received March 19, 2012.
- Accepted March 22, 2012.
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