Del-etion of Microvesicles from the Circulation
Microvesicles (MVs) (also called microparticles) have become a hot topic recently and transport proteins, mRNA and microRNA.1-3 They have been proposed to play roles in numerous processes, including coagulation, inflammation, immune response, cell activation and cancer.1-3 MVs are small (0.1-1 μm) membrane vesicles that are released from activated and apoptotic cells. They contain proteins from their parental cell and are characterized by surface exposure of negatively charged phospholipids, such as phosphatidylserine (PS). Platelets are the primary source of MVs in the circulation of healthy individuals, although other cells also release MVs. Increased levels of MVs are observed in a variety of cardiovascular diseases, including unstable angina, atherosclerosis and inflammatory vascular diseases. Some MV populations are considered as surrogate biomarkers of vascular disorders and of thrombotic risk.2-3 (SELECT FULL TEXT TO CONTINUE)
- Received February 27, 2012.
- Accepted February 29, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited