Of Mice and Children: Lessons from a Kawasaki Mouse Model
Despite 50 years of research, the etiology of Kawasaki disease (KD), the most common cause of acquired heart disease in children, remains a mystery. Fueled by epidemiologic and clinical clues that the disease was triggered by an infectious agent that elicited a dramatic immune response in genetically susceptible children, investigators vigorously searched for the responsible agent1. Thus far, a long list of discarded pathogens is all that remains of these attempts to find the inflammation-causing agent. Application of reverse genetics to engineer synthetic antibodies to track down a putative new virus has shown some promise, but the agent still remains elusive2. (SELECT FULL TEXT TO CONTINUE)
- Received February 15, 2012.
- Accepted February 17, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited