The Uremic Myocardium and Ischemic Tolerance: A World of Difference
Uremia is associated with an increased prevalence of ischemic heart disease. Already at the start of dialysis the prevalence of coronary artery disease is 38%1. The frequency of myocardial infarction in renal patients is high and the outcome is poor2. Despite significant improvement of therapeutic modalities unadjusted 2-year mortality for dialysis patients after acute MI has not changed over the past decades, remaining around approx. 73%2,3. It is of particular note that the risk of cardiac events is 20-fold higher in young adults starting dialysis in the first 2 decades of life compared to an age-matched background population4. (SELECT FULL TEXT TO CONTINUE)
- Received February 6, 2012.
- Accepted February 8, 2012.
- Copyright © 2012, American Heart Association, Inc. All rights reserved. Unauthorized use prohibited