From Pluri- to Multipotency via Vascular Pericytes; Are Mural Cells Guardians of Stemness?
In this issue of Circulation, Dar and collaborators report the healing of ischemic limbs in athymic mice bymultipotent progenitors derived from human embryonic stem cells orreprogrammed adult cells. So far, nothing really original; the excitement comes from the demonstration that these ES- and iPS-cell derived regenerative units exhibit the features of vascular pericytes1. These observations are timely and remarkable inasmuch as the blood vessel, far away from a mere conduit, has lately gained nobility in the eyes of stem cell biologists for its recognized contribution to diverse cell lineages. On the one hand, it is now well accepted that, from fish to humans, specialized "blood-forming" endothelial cells in thedorsal aortaand, most certainly, other organs supply the embryo with hematopoietic cells2-6. (SELECT FULL TEXT TO CONTINUE)
- Received November 8, 2011.
- Accepted November 10, 2011.
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