Iron Deposition in Myocardium Documented on Standard Computed Tomography in Cardiac Hemochromatosis
A 46-year-old woman with pure red-cell aplasia suffered blood transfusion of >200 units, ie, >20 g in iron weight, over 4 years because treatment with a series of immunosuppressants resulted in no effect. Tissue iron deposition caused by iron overload resulted in skin discoloration, hepatic injury, diabetes mellitus, and slight left ventricular dysfunction. Left ventricular end-diastolic and end-systolic dimensions were 45 and 33 mm, respectively, on echocardiogram, and left ventricular ejection fraction was 52%. On standard CT, ie, one scan per 4 seconds, the liver showed a high-density signal before use of contrast medium as a result of iron deposition (Figure 1⇓). On the same series of CT scans, the left ventricular wall could also be identified as a high-density signal, with neither gated scanning nor cine scanning used (Figure 2⇓).
The editor of Images in Cardiovascular Medicine is Hugh A. McAllister, Jr, MD, Chief, Department of Pathology, St Luke’s Episcopal Hospital and Texas Heart Institute, and Clinical Professor of Pathology, University of Texas Medical School and Baylor College of Medicine.
Circulation encourages readers to submit cardiovascular images to Dr Hugh A. McAllister, Jr, St Luke’s Episcopal Hospital and Texas Heart Institute, 6720 Bertner Ave, MC1–267, Houston, TX 77030.
- Copyright © 1998 by American Heart Association