The Effects of Hexamethonium on Certain Manifestations of Congestive Heart Failure
Hypotensive doses of hexamethonium were administered intravenously to 19 patients with various types of heart disease in congestive failure. Clinical improvement as judged by the usual methods was seen in most cases. Intracardiac or pulmonary artery pressures paralleled the fall of arterial pressures following hexamethonium in four patients with hypertensive heart disease in congestive failure. It is suggested that hexamethonium, by reducing the total peripheral resistance and by a redistribution of blood volume, may interrupt the vicious cycle of heart failure.
- © 1953 American Heart Association, Inc.