Correlation of Serum Concentrations with Heart Concentrations of Digoxin in Human Subjects
Biopsies of cardiac tissue were taken from patients undergoing surgery for coronary artery or valvular disease. All subjects were on maintenance doses of digoxin, which were stopped 48 hours before surgery. The ratios, heart:serum, for digoxin content were remarkably similar and the variance was small.
- Received January 15, 1974.
- Accepted June 25, 1974.
- © 1974 American Heart Association, Inc.