Nutritional Factors in Hemodynamics
II. Hypertension during Pteroylglutamic Acid Administration in Albino Rats
Albino rats treated with pteroylglutamic acid (PGA) developed a significant increase in blood pressure, as compared with litter mate controls of the same sex. The hypertension was associated with wedge-shaped fibroblastic renal cortical lesions. Factors possibly important etiologically in the elevation of blood pressure are discussed in relation to certain of the metabolic roles of pteroylglutamic acid.
- © 1952 American Heart Association, Inc.