Clinical Evaluation of 1-Hydrazinophthalazin (C-5968) in Hypertension
With Special Reference to Alternating Treatment With Hexamethonium
Single oral doses of 1-hydrazinophthalazine frequently lowered blood pressure particularly diastolic pressure in hypertensive patients. Prolonged therapy was less successful, apparently as a result of development of tolerance or side effects. The best long-term results were obtained when l-hydrazinophthalazine was alternated with hexamethonium.
- © 1952 American Heart Association, Inc.