Norepinephrine and Epinephrine Effect on Renal Hemodynamics
With Particular Reference to the Possibility of Vascular Shunting and Decreasing the Active Glomeruli
Because increasing evidence suggests that renal ischemia resulting from various stress states plays a major role in the etiology of lower nephron nephrosis, the renal hemodynamic effect of continuous infusions of norepinephrine and epinephrine was studied in dogs. The primary response was a decrease in renal blood flow. As the rate of infusion was increased, a progressive decrease in the number of functioning glomeruli followed. Despite the decrease in renal blood flow, there is no evidence to indicate arteriovenous shunting mechanisms.
- © 1952 American Heart Association, Inc.