An Acute Effect of Cigarette Smoking on Platelet Function
A Possible Link Between Smoking and Arterial Thrombosis
In a controlled, double blind study, the smoking of a single cigarette has been shown to increase the platelet's response to a standard aggregating stimulus. This phenomenon appears to be specifically related to the inhaling of tobacco smoke; it does not follow the smoking of lettuce leaf filled cigarettes. The platelet effect seems independent of the rise in plasma free fatty acids which follows cigarette smoking. Smoking-induced potentiation of platelet aggregation may help to explain the increased incidence of arterial thrombi and/or atheromatous plaques in cigarette smokers.
- Received March 5, 1973.
- Accepted May 4, 1973.
- © 1973 American Heart Association, Inc.