Data from pulmonary angiograms, lung scans, hemodynamic measurements, and tests of fibrinolysis were compared and correlated. In general, there was good correlation of the preinfusion scan perfusion defect with the overall angiographic severity, judged both subjectively and objectively. The highest correlation was obtained when only perfusion defects estimated by the two methods were compared. The correlation was lower when 24-hour changes estimated by scanning and angiography were compared. There was a tendency for the angiogram to reflect greater change.
Hemodynamic abnormalities did not correlate well with the extent of preinfusion involvement judged by scanning or angiography, although in the urokinase patients there was a correlation of the fall in pulmonary arterial mean pressure with scanning or angiographic improvement. This correlation was not present in the patients treated only with heparin.
There was no correlation of degree of fibrinolysis with resolution of emboli as estimated by lung scanning or angiography. This was true in all patients who received urokinase, regardless of initial clot size or degree of change after urokinase infusion.
- © 1973 American Heart Association, Inc.