Skin, kidney, and heart allografts are all rejected acutely by inbred rats when the donor and recipient strains are incompatible at the Ag-B or major rat histocompatibility locus. In contrast, in Ag-B compatible strain combinations, kidney allografts usually survive indefinitely even though skin allografts are still rejected acutely. Unfortunately, matching at major loci may not insure the prolonged survival of organ as opposed to skin allografts in general because heart allografts in the Ag-B compatible Fischer to Lewis strain combination are rejected acutely, like skin.
Evidence that donor pretreatment of rat heart allografts with leukocidal agents can prolong graft survival suggests that the degree of immunogenicity of grafts may be related in part to their leukocyte content.
- © 1970 American Heart Association, Inc.