A satisfactory technique for orthotopic homotransplantation of the heart, under profound hypothermia without a pump-oxygenator, has been presented. Of the 40 puppies in our series, 24 lived more than one day; 13 lived more than seven days. One is well and active on the 112th day. The rhythm of the transplanted hearts was often somewhat irregular shortly after surgery, but usually became fairly regular on the following day and maintained a constant rate even after exercise. Long survivors steadily gained weight and showed a proportional increase in heart size. The fate of the transplant could be forecast in some instances from the follow-up electrocardiograms. Although the histological findings were not uniform, acceptance of the homogous heart greatly exceeded our expectations. Unpredictable histocompatibility may possibly explain the long survivors.
- © 1965 American Heart Association, Inc.