Fluid Retention Produced by Guanethidine
Changes in Body Exchangeable Sodium, Blood Volume, and Creatinine Clearance
Total exchangeable sodium and blood volume increased during the first year's treatment of seven hypertensive patients with guanethidine. Creatinine clearance values fell over the same period.
A similar change was seen in two patients receiving reserpine. It is suggested that the hemodynamic changes produced by hypotensive drugs are insufficient completely to explain the observations. A direct effect of guanethidine on sodium reabsorption in the kidney may also be involved.
- © 1965 American Heart Association, Inc.