These data demonstrate that in normal subjects, angiotensin II is 10 times as potent as norepinephrine which it resembles hemodynamically. An increase in the systolic pressure is associated with a significant increase in diastolic pressure, an increase in venous pressure, a decrease in heart rate, a slight decrease in cardiac output and a striking increase in total peripheral resistance, a decrease in renal blood flow, decreased glomerular filtration rate, increase in filtration fraction, and slight decrease in urinary volume.
Preliminary studies in patients in shock suggest that angiotensin II is 2 or 3 times as potent as norepinephrine. Continuous administration is not associated with the development of tachyphylaxis, and sloughing of tissues does not occur if there is leakage outside the vein.
- © 1962 American Heart Association, Inc.