The Use of Ascorbate Dilution Curves in Cardiovascular Diagnosis
Applications of a Technic for Direct Intravascular Detection of Indicator
The instrumentation and clinical applications, in this laboratory, of Clark's sodium ascorbate dilution technic are described. With this method the sensing device, a platinum electrode, is introduced directly into the blood stream, and a reducing agent, sodium ascorbate, is used as the indicator. Time-concentration curves may be obtained without the withdrawal of blood. Observations in 90 patients have indicated that the contours of the dilution curves are essentially identical to indocyanine-green dye-dilution curves, except for diminished peripheral recirculation peaks. The ascorbate-dilution technic has been found of particular value when the sensing electrode is incorporated into a cardiac catheter. This method permits injection and sampling of the indicator from the central circulation and greatly facilitates the study of circulatory shunts and of valvular regurgitation.
- © 1961 American Heart Association, Inc.