A protein molecule in solution may undergo a host of interactions: with solvent, with small molecules and ions, with itself, with other macromolecules. In a physiologic milieu, all of these possibilities are present. A variety of interactions will occur. On the basis of the behavior of these substances in simple systems, reasonable guesses can often be made as to which interactions will predominate in a biologic environment.
- © 1960 American Heart Association, Inc.