Lipoproteins, Cholesterol and Serum Proteins as Predictors of Myocardial Infarction
The normal variability of lipoprotein and cholesterol levels was established for 6 women over a period of 5 months for comparison with levels in people who develop myocardial infarction. We have studied 107 normal men for 7 years. Among these 11 developed infarction and 6 angina pectoris. Little change in lipid levels was associated with these events. Electrophoretic patterns early after infarction showed certain relatively characteristic changes, especially increase in α-2 and β globulins and fibrinogen. Low-density lipoprotein also increased. While α-2 globulin was usually greatest in patients with the most extensive myocardial damage, there was little over-all correlation between lipoprotein pattern and severity of infarction. The "coronary profile" can be more sharply delineated by repeated lipid measurements because as a group those with atherosclerosis and infarction exhibit slightly elevated values.
- © 1959 American Heart Association, Inc.