Plasma Turbidity Changes and Electrocardiographic Alterations Induced by Alimentary Hyperlipemia in Anginal Patients before and after the Administration of Gastric Mucin
The hyperlipemia induced by a fat meal in anginal patients is frequently associated with clinical and electrocardiographic changes suggesting transient coronary insufficiency. Gastric mucin administered to 10 anginal patients at the same time as a fat meal invariably prevented the hyperlipemia, evaluated as increase of plasma optical density, and in one half of the cases it reduced the magnitude of the electrocardiographic changes as compared with the changes found in control experiments. Gastric mucin therefore exerts a powerful antilipemic and clearing action. Its inhibitory effect on the electrocardiographic changes associated with alimentary hyperlipemia is less evident than that of heparin.
- © 1958 American Heart Association, Inc.