Intramuscular injection of various kidney extracts containing renin in several animal species caused the appearance in sera of a substance which neutralized renin. The antirenin titers of the antisera were determined by assaying the quantity of unneutralized renin. The assay was based on the production of angiotonin. The dog differs from the other species studied in that heterologous kidney extracts cause a production of antibodies against the treated animal's own renin.
- © 1958 American Heart Association, Inc.