Letter by Jin-shan and Xue-bin Regarding Article, “Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions”

He Jin-shan; Li Xue-bin

doi:10.1161/CIRCULATIONAHA.117.030675

To the Editor:

We read with great interest the article by Saleheen et al¹ about the interaction of smoking behavior with genotypes associated with coronary heart disease (CHD) risk, which indicates that reduced ADAMTS7 expression confers stronger CHD protection in never-smokers than in ever-smokers, and increased vascular ADAMTS7 expression may contribute to the loss of CHD protection in smokers. This study is a large data and deeper level analysis that identifies gene-environment interactions. We have several questions about this study. First, reduced ADAMTS7 expression has strong CHD protection effect, and inhibition of ADAMTS7 is a novel potential therapeutic strategy for CHD. What is mechanism of CHD protection of ADAMTS7? Does it have an effect on other cardiovascular risk factors such as hypertensionand diabetes mellitus? Will it ehance their harm on the cardiovascular system? Is the inhibition of it only effective in smokers? Can more protection be obtained by inhibiting it in never-smokers? Second, rs7178051 associated with ADAMTS7 is only 220 KB away from rs1051730, a single-nucleotide polymorphism in a cluster of cholinergic nicotinic receptor genes (A3-A5) previously associated with nicotine dependence and lung cancer.² Do they have common pathogenesis mechanisms? Can we find a common target to reduce the risk of both CHD and lung cancer?

He Jin-shan, MD

Li Xue-bin, MD

Disclosures

None.

Footnotes

Circulation is available at http://circ.ahajournals.org.

References

1.↵
1. Saleheen D,
2. Zhao W,
3. Young R,
4. Nelson CP,
5. Ho W,
6. Ferguson JF,
7. Rasheed A,
8. Ou K,
9. Nurnberg ST,
10. Bauer RC,
11. Goel A,
12. Do R,
13. Stewart AFR,
14. Hartiala J,
15. Zhang W,
16. Thorleifsson G,
17. Strawbridge RJ,
18. Sinisalo J,
19. Kanoni S,
20. Sedaghat S,
21. Marouli E,
22. Kristiansson K,
23. Hua Zhao J,
24. Scott R,
25. Gauguier D,
26. Shah SH,
27. Smith AV,
28. van Zuydam N,
29. Cox AJ,
30. Willenborg C,
31. Kessler T,
32. Zeng L,
33. Province MA,
34. Ganna A,
35. Lind L,
36. Pedersen NL,
37. White CC,
38. Joensuu A,
39. Edi Kleber M,
40. Hall AS,
41. März W,
42. Salomaa V,
43. O’Donnell C,
44. Ingelsson E,
45. Feitosa MF,
46. Erdmann J,
47. Bowden DW,
48. Palmer CNA,
49. Gudnason V,
50. Faire U,
51. Zalloua P,
52. Wareham N,
53. Thompson JR,
54. Kuulasmaa K,
55. Dedoussis G,
56. Perola M,
57. Dehghan A,
58. Chambers JC,
59. Kooner J,
60. Allayee H,
61. Deloukas P,
62. McPherson R,
63. Stefansson K,
64. Schunkert H,
65. Kathiresan S,
66. Farrall M,
67. Marcel Frossard P,
68. Rader DJ,
69. Samani NJ,
70. Reilly MP
. Loss of cardioprotective effects at the ADAMTS7 locus as a result of gene-smoking interactions. Circulation. 2017;135:2336–2353. doi: 10.1161/CIRCULATIONAHA.116.022069.
OpenUrl Abstract/FREE Full Text
2.↵
1. Hung RJ,
2. McKay JD,
3. Gaborieau V,
4. Boffetta P,
5. Hashibe M,
6. Zaridze D,
7. Mukeria A,
8. Szeszenia-Dabrowska N,
9. Lissowska J,
10. Rudnai P,
11. Fabianova E,
12. Mates D,
13. Bencko V,
14. Foretova L,
15. Janout V,
16. Chen C,
17. Goodman G,
18. Field JK,
19. Liloglou T,
20. Xinarianos G,
21. Cassidy A,
22. McLaughlin J,
23. Liu G,
24. Narod S,
25. Krokan HE,
26. Skorpen F,
27. Elvestad MB,
28. Hveem K,
29. Vatten L,
30. Linseisen J,
31. Clavel-Chapelon F,
32. Vineis P,
33. Bueno-de-Mesquita HB,
34. Lund E,
35. Martinez C,
36. Bingham S,
37. Rasmuson T,
38. Hainaut P,
39. Riboli E,
40. Ahrens W,
41. Benhamou S,
42. Lagiou P,
43. Trichopoulos D,
44. Holcátová I,
45. Merletti F,
46. Kjaerheim K,
47. Agudo A,
48. Macfarlane G,
49. Talamini R,
50. Simonato L,
51. Lowry R,
52. Conway DI,
53. Znaor A,
54. Healy C,
55. Zelenika D,
56. Boland A,
57. Delepine M,
58. Foglio M,
59. Lechner D,
60. Matsuda F,
61. Blanche H,
62. Gut I,
63. Heath S,
64. Lathrop M,
65. Brennan P
. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008;452:633–637. doi: 10.1038/nature06885.
OpenUrl CrossRef PubMed

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Letter by Jin-shan and Xue-bin Regarding Article, “Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions”

He Jin-shan and Li Xue-bin

Circulation. 2018;137:215-216, originally published January 8, 2018
https://doi.org/10.1161/CIRCULATIONAHA.117.030675

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Cited By...

Subjects

[1] 1.↵
Saleheen D,
Zhao W,
Young R,
Nelson CP,
Ho W,
Ferguson JF,
Rasheed A,
Ou K,
Nurnberg ST,
Bauer RC,
Goel A,
Do R,
Stewart AFR,
Hartiala J,
Zhang W,
Thorleifsson G,
Strawbridge RJ,
Sinisalo J,
Kanoni S,
Sedaghat S,
Marouli E,
Kristiansson K,
Hua Zhao J,
Scott R,
Gauguier D,
Shah SH,
Smith AV,
van Zuydam N,
Cox AJ,
Willenborg C,
Kessler T,
Zeng L,
Province MA,
Ganna A,
Lind L,
Pedersen NL,
White CC,
Joensuu A,
Edi Kleber M,
Hall AS,
März W,
Salomaa V,
O’Donnell C,
Ingelsson E,
Feitosa MF,
Erdmann J,
Bowden DW,
Palmer CNA,
Gudnason V,
Faire U,
Zalloua P,
Wareham N,
Thompson JR,
Kuulasmaa K,
Dedoussis G,
Perola M,
Dehghan A,
Chambers JC,
Kooner J,
Allayee H,
Deloukas P,
McPherson R,
Stefansson K,
Schunkert H,
Kathiresan S,
Farrall M,
Marcel Frossard P,
Rader DJ,
Samani NJ,
Reilly MP
. Loss of cardioprotective effects at the ADAMTS7 locus as a result of gene-smoking interactions. Circulation. 2017;135:2336–2353. doi: 10.1161/CIRCULATIONAHA.116.022069.
OpenUrl Abstract/FREE Full Text

[2] Saleheen D,

[3] Zhao W,

[4] Young R,

[5] Nelson CP,

[6] Ho W,

[7] Ferguson JF,

[8] Rasheed A,

[9] Ou K,

[10] Nurnberg ST,

[11] Bauer RC,

[12] Goel A,

[13] Do R,

[14] Stewart AFR,

[15] Hartiala J,

[16] Zhang W,

[17] Thorleifsson G,

[18] Strawbridge RJ,

[19] Sinisalo J,

[20] Kanoni S,

[21] Sedaghat S,

[22] Marouli E,

[23] Kristiansson K,

[24] Hua Zhao J,

[25] Scott R,

[26] Gauguier D,

[27] Shah SH,

[28] Smith AV,

[29] van Zuydam N,

[30] Cox AJ,

[31] Willenborg C,

[32] Kessler T,

[33] Zeng L,

[34] Province MA,

[35] Ganna A,

[36] Lind L,

[37] Pedersen NL,

[38] White CC,

[39] Joensuu A,

[40] Edi Kleber M,

[41] Hall AS,

[42] März W,

[43] Salomaa V,

[44] O’Donnell C,

[45] Ingelsson E,

[46] Feitosa MF,

[47] Erdmann J,

[48] Bowden DW,

[49] Palmer CNA,

[50] Gudnason V,

[51] Faire U,

[52] Zalloua P,

[53] Wareham N,

[54] Thompson JR,

[55] Kuulasmaa K,

[56] Dedoussis G,

[57] Perola M,

[58] Dehghan A,

[59] Chambers JC,

[60] Kooner J,

[61] Allayee H,

[62] Deloukas P,

[63] McPherson R,

[64] Stefansson K,

[65] Schunkert H,

[66] Kathiresan S,

[67] Farrall M,

[68] Marcel Frossard P,

[69] Rader DJ,

[70] Samani NJ,

[71] Reilly MP

[72] 2.↵
Hung RJ,
McKay JD,
Gaborieau V,
Boffetta P,
Hashibe M,
Zaridze D,
Mukeria A,
Szeszenia-Dabrowska N,
Lissowska J,
Rudnai P,
Fabianova E,
Mates D,
Bencko V,
Foretova L,
Janout V,
Chen C,
Goodman G,
Field JK,
Liloglou T,
Xinarianos G,
Cassidy A,
McLaughlin J,
Liu G,
Narod S,
Krokan HE,
Skorpen F,
Elvestad MB,
Hveem K,
Vatten L,
Linseisen J,
Clavel-Chapelon F,
Vineis P,
Bueno-de-Mesquita HB,
Lund E,
Martinez C,
Bingham S,
Rasmuson T,
Hainaut P,
Riboli E,
Ahrens W,
Benhamou S,
Lagiou P,
Trichopoulos D,
Holcátová I,
Merletti F,
Kjaerheim K,
Agudo A,
Macfarlane G,
Talamini R,
Simonato L,
Lowry R,
Conway DI,
Znaor A,
Healy C,
Zelenika D,
Boland A,
Delepine M,
Foglio M,
Lechner D,
Matsuda F,
Blanche H,
Gut I,
Heath S,
Lathrop M,
Brennan P
. A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25. Nature. 2008;452:633–637. doi: 10.1038/nature06885.
OpenUrl CrossRef PubMed

[73] Hung RJ,

[74] McKay JD,

[75] Gaborieau V,

[76] Boffetta P,

[77] Hashibe M,

[78] Zaridze D,

[79] Mukeria A,

[80] Szeszenia-Dabrowska N,

[81] Lissowska J,

[82] Rudnai P,

[83] Fabianova E,

[84] Mates D,

[85] Bencko V,

[86] Foretova L,

[87] Janout V,

[88] Chen C,

[89] Goodman G,

[90] Field JK,

[91] Liloglou T,

[92] Xinarianos G,

[93] Cassidy A,

[94] McLaughlin J,

[95] Liu G,

[96] Narod S,

[97] Krokan HE,

[98] Skorpen F,

[99] Elvestad MB,

[100] Hveem K,

[101] Vatten L,

[102] Linseisen J,

[103] Clavel-Chapelon F,

[104] Vineis P,

[105] Bueno-de-Mesquita HB,

[106] Lund E,

[107] Martinez C,

[108] Bingham S,

[109] Rasmuson T,

[110] Hainaut P,

[111] Riboli E,

[112] Ahrens W,

[113] Benhamou S,

[114] Lagiou P,

[115] Trichopoulos D,

[116] Holcátová I,

[117] Merletti F,

[118] Kjaerheim K,

[119] Agudo A,

[120] Macfarlane G,

[121] Talamini R,

[122] Simonato L,

[123] Lowry R,

[124] Conway DI,

[125] Znaor A,

[126] Healy C,

[127] Zelenika D,

[128] Boland A,

[129] Delepine M,

[130] Foglio M,

[131] Lechner D,

[132] Matsuda F,

[133] Blanche H,

[134] Gut I,

[135] Heath S,

[136] Lathrop M,

[137] Brennan P

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Letter by Jin-shan and Xue-bin Regarding Article, “Loss of Cardioprotective Effects at the ADAMTS7 Locus as a Result of Gene-Smoking Interactions”

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