Response by Sharma et al to Letter Regarding Article, “The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus”
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Tang and colleagues raise 3 pertinent issues related to our study1 and its related findings.
First, they seek clarification regarding the prevalence of observed leaflet thrombosis across the different inflation parameters quoted in a prior study2 arising from a similar data pool. In addition, they question the potential suggestion that nominal inflation should be avoided given the presence of thrombus in valves expanded <100%.
Although the data from this study originated from the same registry as the previously quoted study by Kazuno et al,2 there is no way to determine which, if any, of the 39 patients in that study overlap with the 72 cases in our study, as all data were deidentified.
This study is a purely mechanistic …