Letter by Tang et al Regarding Article, “The Fluid Mechanics of Transcatheter Heart Valve Leaflet Thrombosis in the Neosinus”
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To the Editor:
We read with great interest the article by Midha and colleagues1 on thrombus formation in the neosinus after transcatheter aortic valve replacement. The authors reported that thrombus formation was associated with a nominal or overexpanded Sapien 3 (S3) valve (Edwards Lifesciences LLC, Irvine, CA) and deeper implantation of the CoreValve (Medtronic Inc, Galway, Ireland). They also reported that intraannular or subannular leaflet position and reduced cardiac output increased stasis in the neosinus and native sinuses. We have 3 questions for the authors. First, the mean expansion of S3 by diameter in the thrombus group was 95.2±5.2%, which was similar to that reported by the same group using the RESOLVE registry …