Response by Olde Engberink et al to Letter Regarding Article, “Use of a Single Baseline Versus Multiyear 24-Hour Urine Collection for Estimation of Long-Term Sodium Intake and Associated Cardiovascular and Renal Risk”

In Response:

We thank Graudal and Mente for their interest in our article.¹ We would like to clarify the authors’ comment that the confidence intervals indicate no outcome difference between baseline and follow-up measurements. The overlapping confidence intervals do not indicate absence of significance between both regression lines because they reflect confidence intervals that accompany the hazard ratios compared with a 2-g sodium intake. Moreover, we want to stress that both regression lines are based on the same dependent variable (ie, estimated sodium intake) and do not represent 2 different interventions. Therefore, these data seem to be a logical consequence of the large changes in sodium excretion …