Letter by Mansour et al Regarding Article, “Early Use of N-Acetylcysteine With Nitrate Therapy in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Reduces Myocardial Infarct Size (the NACIAM Trial [N-Acetylcysteine in Acute Myocardial Infarction])”
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To the Editor:
We read with great interest the article by Pasupathy et al1 reporting the beneficial role of the early administration of intravenous N-acetylcysteine with low-dose intravenous nitroglycerin in patients with acute ST-segment–elevation myocardial infarction undergoing primary percutaneous coronary intervention.
N-Acetylcysteine (NAC), by disrupting the disulfide bond in the von …