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Correspondence

Response by Wolters and Ikram to Letter Regarding Article, “Cerebral Perfusion and the Risk of Dementia: A Population-Based Study”

Frank J. Wolters, M. Arfan Ikram
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https://doi.org/10.1161/CIRCULATIONAHA.117.032341
Circulation. 2018;137:1416-1417
Originally published March 26, 2018
Frank J. Wolters
Department of Epidemiology (F.J.W., M.A.I.)Department of Neurology (F.J.W.), Erasmus Medical Centre, Rotterdam, The Netherlands
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M. Arfan Ikram
Department of Epidemiology (F.J.W., M.A.I.)
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In Response:

Cerebral perfusion depends on a wide range of, often modifiable, physiological circumstances, and the majority of these factors have also been linked to the risk of developing dementia in the community. Atrial fibrillation and cardiorespiratory fitness are 2 such important determinants with a high potential for preventive intervention, and we appreciate the replies to our recent article1 by Dr Cerit and Dr Bailey and colleagues, which emphasize the need to investigate the relation of these factors with cognitive decline in the context of cerebral hemodynamics.

Prior studies, including Rotterdam Study reports, have found …

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March 27, 2018, Volume 137, Issue 13
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    Response by Wolters and Ikram to Letter Regarding Article, “Cerebral Perfusion and the Risk of Dementia: A Population-Based Study”
    Frank J. Wolters and M. Arfan Ikram
    Circulation. 2018;137:1416-1417, originally published March 26, 2018
    https://doi.org/10.1161/CIRCULATIONAHA.117.032341

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    Response by Wolters and Ikram to Letter Regarding Article, “Cerebral Perfusion and the Risk of Dementia: A Population-Based Study”
    Frank J. Wolters and M. Arfan Ikram
    Circulation. 2018;137:1416-1417, originally published March 26, 2018
    https://doi.org/10.1161/CIRCULATIONAHA.117.032341
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