Response by Wolters and Ikram to Letter Regarding Article, “Cerebral Perfusion and the Risk of Dementia: A Population-Based Study”
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Cerebral perfusion depends on a wide range of, often modifiable, physiological circumstances, and the majority of these factors have also been linked to the risk of developing dementia in the community. Atrial fibrillation and cardiorespiratory fitness are 2 such important determinants with a high potential for preventive intervention, and we appreciate the replies to our recent article1 by Dr Cerit and Dr Bailey and colleagues, which emphasize the need to investigate the relation of these factors with cognitive decline in the context of cerebral hemodynamics.
Prior studies, including Rotterdam Study reports, have found …