Letter by Bailey et al Regarding Article, “Cerebral Perfusion and the Risk of Dementia: A Population-Based Study”
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To the Editor:
We read with interest the recent publication by Wolters et al1 highlighting cerebral hypoperfusion as an independent risk factor for accelerated cognitive decline and increased risk of dementia in the general population. Because curative treatments for dementia are currently unavailable, future efforts that seek to promote lifelong brain health need to focus on prevention with a specific emphasis on modifiable risk factors. Thus, it was unfortunate that the authors did not consider baseline cardiorespiratory fitness as an additional input variable in their overall analysis given the potential for exercise to restore the inexorable decline in cerebral perfusion that defines sedentary ageing. Here, we take the opportunity to further translate …