Letter by Zhu et al Regarding Article, “Aortic Wall Inflammation Predicts Abdominal Aortic Aneurysm Expansion, Rupture, and Need for Surgical Repair”
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To the Editor:
We read with great interest the article by the MA3RS Study Group regarding abdominal aortic aneurysms (AAAs) in Circulation.1 Three hundred forty-two patients with AAAs (average diameter ≈5 cm) were studied using ultrasmall superparamagnetic iron oxide particle (USPIO)–enhanced magnetic resonance imaging (MRI) and followed with ultrasound for ≥2 years. Although USPIO enhancement was associated with faster growth and AAA rupture or repair, it was not an independent predictor of clinical outcome. Nonetheless, we believe that molecular imaging with this novel MRI contrast agent has promise for better understanding of AAA disease progression.
Although the ultrasound reproducibility (3.5%) reported in …