Abstract 15119: Consumption of a Defined Plant Based Diet Reduces Lp(a) and Other Atherogenic Lipoproteins and Particles in Four Weeks
Introduction: Lipoprotein(a) [Lp(a)] is a highly atherogenic lipoprotein and is minimally effected by lifestyle changes. No medical therapy has consistently shown definitive reduction of Lp(a). The effect of consuming a plant-based diet on serum Lp(a) concentrations have not been previously evaluated.
Hypothesis: Based on previous investigations demonstrating dramatic reductions in serum lipoproteins, it was hypothesized that serum Lp(a) concentrations could also be reduced. Thus, we sought to investigate whether a defined, plant-based dietary intervention could reduce Lp(a) concentrations and other atherogenic lipoproteins and particles.
Methods: Overweight and obese individuals with low-density lipoprotein cholesterol concentrations >100 mg/dL participated in the intervention in a clinical setting. Subjects (n=31) consumed a defined, plant-based diet for four weeks. Baseline and 4-week labs were collected. Data were analyzed using a paired samples t-test.
Results: Significant reductions were observed for serum Lp(a) (-29.5 ± 9.3 nmol/L, P = 0.004), total cholesterol (-33.8 ± 4.6 mg/dL, P <0.0005), LDL-C (-24.6 ± 3.8 mg/dL, P <0.0005), HDL-C (-5.2 ± 1.1 mg/dL, P = 0.004), triglycerides (-19.6 ± 6.9 mg/dL, P = 0.008), apolipoprotein B (-13.2 ± 3.2 mg/dL, P <0.0005), LDL particles (-304.8 ± 67.4 nmol/L, P <0.0005), small-dense LDL-C (-10.0 ± 1.6 mg/dL, P <0.0005), HDL2-C (-1.8 ± 0.8 mg/dL, P = 0.030) and apolipoprotein A-1 (-27.0 ± 3.5 mg/dL, P <0.0005).
Conclusions: A defined, plant-based diet has a favorable impact on Lp(a) and other atherogenic lipoproteins and particles. Lp(a) concentration was previously thought to be only minimally altered by interventions. In this protocol however, a defined plant-based diet was shown to have a significant impact on this biomarker. Further investigations are required to elucidate the specific mechanisms that contribute to the reductions in Lp(a) concentrations, which may include alterations in gene expression.
Author Disclosures: R.S. Najjar: None. F.A. Laws: None. C.E. Moore: None. B.D. Montgomery: None.
- © 2017 by American Heart Association, Inc.