Abstract 14554: Contemporary Appraisal of Sex Differences in Prevalence, Correlates, and Outcomes of Alcoholic Cardiomyopathy in the United States
Introduction: Alcoholic cardiomyopathy (ACM) is a specific heart muscle disease found in individuals with a history of long-term heavy alcohol consumption. In spite of its adverse impact, data related to sex differences in the prevalence, correlates, and outcomes of ACM are sparse.
Methods: We used the Nationwide Inpatient Sample (NIS) dataset (2002-2014) to examine the role of sex in prevalence, correlates, and outcomes of ACM among adults ≥21 years of age. International Classification of Diseases, Ninth Revision, Clinical Modifications (ICD-9-CM) codes were used to define cases, comorbidities, and other clinical outcomes. Rates of ACM among men and women were calculated by patient and hospital characteristics. Survey logistic regression was used to estimate odds ratios (OR) that represent the association between ACM and outcomes separately for men and women. Joinpoint regression was used to describe temporal trends, particularly the annual percent change (APC), in ACM prevalence and in-hospital mortality rates.
Results: Among 402 million adult (≥ years of age) inpatient hospitalizations from 2002-2014, a total of 207,729 (0.05%) and 31,331 (0.01%) had an inpatient diagnosis of ACM. Among men, rates of ACM decreased significantly by 1.3% annually (2002-2010) and increased by 1% annually (2010-2014). Conversely, the ACM rate remained stable for women throughout the study period. Women with ACM were over 2 times (OR=2.4, 95% CI: 2.2-2.8) more likely to die than their counterparts without ACM. Men with ACM are 40% more likely (OR=1.4, 95% CI: 1.3-1.5) to die than men without ACM. Women with ACM were also 84% and 2 times more likely than men with ACM to experience anxiety and depression respectively.
Conclusions: Although women comprise only 13.1% of all ACM-related hospitalizations, women with ACM are more likely to die relative to non-ACM women than men with ACM are to die compared to non-ACM men. Future studies should attempt to further elucidate reasons behind this phenomenon.
Author Disclosures: M.F. Mogos: None. J.L. Salemi: None. K.D. Russell: None. M.R. Piano: None.
- © 2017 by American Heart Association, Inc.