Letter by Rowshani et al Regarding Article, “Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection”
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To the Editor:
We read with great interest the results of “Gene Expression Profiling for the Identification and Classification of Antibody Mediated Heart Rejection” by Loupy et al.1 The authors compared endomyocardial biopsies of patients with acute antibody-mediated rejection (n=55) with a matched control group of 55 patients without antibody-mediated rejection using histopathology (International Society for Heart and Lung Transplantation 2013 grades), immunostaining, and circulating anti-human leukocyte antigen donor–specific antibodies at the time of biopsy, together with systematic gene expression assessments of the allograft tissue using microarrays. Effector cells were evaluated using in vitro human cell cultures. The results were validated in a cohort of 98 …