Response by Chatterjee et al to Letter Regarding Article, “Genetic Obesity and the Risk of Atrial Fibrillation: Causal Estimates From Mendelian Randomization”
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We thank Dr Koh for his interest in and comments on our work. We agree that the relationship between obesity and cardiovascular disease is nuanced and, more specifically, that measures of adiposity beyond body mass index may provide incremental prognostic and mechanistic insight. In the context of atrial fibrillation (AF), our publication discusses several potential mechanisms …