Response by Caillon et al to Letter Regarding Article, “γδ T Cells Mediate Angiotensin II-Induced Hypertension and Vascular Injury”
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Dr Campbell raises the concern regarding our study on γδ T cells and hypertension1 that the dose (490 ng·kg–1·min–1) and subcutaneous route of angiotensin II infusion is too high in comparison with that required to increase blood pressure intravenously.2 There are indeed important differences in bioavailability between both routes of administration. The dose of 490 ng·kg–1·min–1 induces similar pressor responses and plasma levels in rats as intravenous angiotensin II at 20 ng·kg–1·min–1, according to Dr Campbell’s own review from a few years ago.2 He points out that high concentrations of angiotensin II delivered into the subcutaneous tissue may activate a variety of cells expressing angiotensin receptors, including T …