Letter by Campbell Regarding Article, “γδ T Cells Mediate Angiotensin II-Induced Hypertension and Vascular Injury”
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To the Editor:
Caillon et al1 report that angiotensin (Ang) II infusion increased blood pressure, decreased endothelial function, and increased γδ T-cell numbers and activation in the spleen of mice, and that the blood pressure and endothelial responses were abrogated by Tcrδ gene knockout and blunted by γδ T-cell depletion with an anti–T-cell receptor (TCR) γδ antibody. They also report that systolic blood pressure was associated with whole blood TCR γ constant region gene expression in a cohort of patients who had undergone coronary angiography. They conclude that γδ T cells mediate Ang II–induced blood pressure elevation, vascular injury, and T-cell activation in mice, and speculate that γδ T …