Mild Thyroid Dysfunction
A Potential Target in Prevention of Atrial Fibrillation?
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Article, see p 2100
The association between thyroid dysfunction and atrial fibrillation (AF) is well known and has been described in both experimental and epidemiological studies. Recently, there has been a growing interest in whether the risk of AF is elevated in milder degrees of thyroid dysfunction, ie, high-normal thyroid function with thyroid-stimulating hormone (TSH) and free thyroxine (fT4) within the normal reference ranges.1,2 Subclinical hypothyroidism is a common condition with an overall prevalence of 4% in the United States reported by the National Health and Nutrition Examination Survey III, increasing to 10% in the elderly population of the Framingham Study. In general, the prevalence and incidence of subclinical hypothyroidism increases with age, autoimmunity, iodine status, and female sex, and it is associated with several cardiovascular risk factors.3–5 In this issue of Circulation, Baumgartner et al6 from the Thyroid Studies Collaboration present an …