Response by Sag et al to Letter Regarding Article, “Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure”
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We thank Violi and colleagues for their interest in our study.1 As noted, a growing body of evidence suggests an important involvement of Nox2 in hypertension related to a pathologically activated renin angiotensin system. This includes highly specific gene-modification studies in mouse models1,2 as well as correlative studies in humans, such as those discussed by the authors. Taken together, these results …