Letter by Violi et al Regarding Article, “Distinct Regulatory Effects of Myeloid Cell and Endothelial Cell NAPDH Oxidase 2 on Blood Pressure”
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To the Editor:
Nox2 is among the most important cellular producers of reactive oxidant species, which play a major role for bacteria defense by innate immune cells.1 However, Nox2 is also expressed by artery vessels, where it possesses a vasoconstrictive property.1 Thus, compared with controls, in patients with chronic granulomatous disease, a rare illness characterized prevalently by X-linked Nox2 hereditary deficiency and life-threatening infections,1 an enhanced artery dilatation was detected.2,3 This …