Letter by Zimmermann et al Regarding Article, “Excess Cardiovascular Risk in Women Relative to Men Referred for Coronary Angiography Is Associated With Severely Impaired Coronary Flow Reserve, Not Obstructive Disease”
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To the Editor:
We read with interest the study by Taqueti et al1 regarding the relation of positron emission tomography–derived coronary flow reserve (CFR) and the risk of adverse cardiovascular events between men and women. The authors found an association of CFR and excess cardiovascular risk in women. They conclude that CFR itself, particularly in the absence of severe coronary artery disease, may represent a novel target for cardiovascular disease risk reduction. Although the study tries to unravel the complex interplay between sex, coronary physiology, ischemia, and heart failure, some issues should be considered in the interpretation of the …