Sedentary Behavior and Subclinical Cardiac Injury
Results From the Dallas Heart Study
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Chronic subclinical myocardial injury, detectable with high-sensitivity assays for cardiac troponin T (hs-cTnT) and I (hs-cTnI), is associated with increased risk for incident heart failure and mortality among asymptomatic individuals without known cardiovascular disease (CVD). Prevention or attenuation of myocardial injury therefore may represent an effective strategy for heart failure prevention. To that end, several preliminary studies have observed favorable effects of higher levels of physical activity on high-sensitivity troponin levels,1,2 an observation that may provide mechanistic insight into larger studies demonstrating a dose-dependent reduction in heart failure risk with increased physical activity.3,4 Adults spend significantly more time being sedentary than they do performing moderate to vigorous physical activity (MVPA), and some studies have suggested that exercise does not abrogate the cardiovascular hazards of prolonged sedentary behavior.5 Although increased sedentary time has been associated with an increase in all-cause mortality and heart failure independent of regular exercise,3,5 no data are available describing the effects of sedentary time on chronic myocardial injury. We hypothesized that increased sedentary time would be associated with higher levels of hs-cTnT and hs-cTnI among individuals in the general population who are free from CVD.
To test this hypothesis, we performed a cross-sectional study that included participants completing the phase 2 visit of the …