Response by Bress et al to Letters Regarding Article, “Potential Deaths Averted and Serious Adverse Events Incurred From Adoption of the SPRINT (Systolic Blood Pressure Intervention Trial) Intensive Blood Pressure Regimen in the United States: Projections from NHANES (National Health and Nutrition Examination Survey)”
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We thank Dr Koh for his comments and agree that clinical practice guidelines should evolve as new knowledge becomes available. For example, a recent network meta-analysis of 42 blood pressure–lowering trials including 144 220 patients found significantly lower risks of all-cause mortality among participants who achieved systolic blood pressure 120 to 124 mm Hg in comparison with all other achieved systolic blood pressure groups including 130 to 134, 140 to 144, 150 to 154, or 160 mm Hg or more.1 Specifically, randomized groups who achieved a mean systolic …