Letter by Donzelli Regarding Article, “Potential Deaths Averted and Serious Adverse Events Incurred From Adoption of the SPRINT (Systolic Blood Pressure Intervention Trial) Intensive Blood Pressure Regimen in the United States: Projections From NHANES (National Health and Nutrition Examination Survey)”
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To the Editor:
If SPRINT (Systolic Blood Pressure Intervention Trial) eligibility criteria were applied to the 1999 to 2006 NHANES (National Health and Nutrition Examination Survey), Bress and colleagues1 calculate that lowering systolic blood pressure (BP) to an intensive goal of <120 mm Hg (versus the standard goal of <140 mm Hg) could prevent ≈107 500 deaths per year, despite a higher incidence of treatment-related serious adverse events.
A sensitivity analysis has tried to take into account the different methods of BP measurements in NHANES and SPRINT, finding reduced but still significant outcomes.
The SPRINT methodology is not usually used in clinical practice. BP was measured at an office visit, in participants sitting quietly …