Letter by Ferrero et al Regarding Article, “Predictors of Death in Contemporary Adult Patients With Eisenmenger Syndrome: A Multicenter Study”
This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
To the Editor:
We read with interest the article by Kempny et al,1 who developed a multivariate prognostic model to stratify the risk of death in patients with Eisemenger syndrome. This study represents a pivotal contribution to the clinical management of patients with congenital heart disease, whose underlying pathophysiology is usually too complex and heterogeneous to allow any standardization of prognosis estimation.
From the methodological point of view, it should be recognized that every prognostic model is based on some fundamental constitutive feature that must be systematically appraised: determination cohort, selection of relevant variables, validation …