Abstract P378: Association Between an Ideal Cardiovascular Health (ICH) Profile and Coronary Artery Calcium (CAC) in South Asians: Implications for the Role of Lifestyle Factors in the Prevention of Cardiovascular Disease in a Minority Population.
The goal of this study was to evaluate cross sectionally the association between an ideal cardiovascular risk factor (IRF) profile and the presence and severity of subclinical atherosclerosis measured in the form of coronary artery calcium (CAC) at the El Camino Hospital South Asian Heart Center. We included 515 participants of South Asian origin with no prior history of cardiovascular disease aged 36 to 88 years who underwent CAC measurement. The 2010 Task Force of the American Heart Association (AHA) cutoffs were used to define ideal level of smoking, physical activity, diet, blood pressure, glucose, cholesterol levels, and body mass index (BMI). Participants were categorized according their number of IRFs: 0 to 1 (n = 45, 8.7%), 2 (n = 103, 20%), 3 (n = 144, 28%), 4 (n = 128, 24.9%), 5 (n = 70, 13.6%), and 6 to 7 (n = 25, 4.8%). Compared to individuals with 0 to 1 IRFs, the odds ratio of participants with 6 to 7 IRFs presenting with a CAC >0 was 0.16 (95% CI 0.04-0.69). Moving forward, participants were also categorized according to their number of ideal lifestyle factors (BMI, physical activity, smoking status, and healthy diet) and clinical factors (blood pressure, total cholesterol, and blood sugar). Compared to individuals with 0 ideal lifestyle factors, the odds ratio of participants with all 4 ideal lifestyle factors presenting with a CAC >0 was .12 (95% CI .03-.50). Amongst the individual ideal lifestyle factors though, only non-smoking status, 0.47 (95% CI 0.30-.75), and a BMI <23 kg/m^2, 0.60 (95% CI 0.38-.95), conferred a statistically significant protective effect from having a non-zero CAC score. In contrast, compared to those with 0 ideal clinical factors, the odds ratio of participants with all 3 ideal clinical factors presenting with a CAC >0 was .16 (95% CI .06-.44). That said, amongst the individual ideal clinical factors, normal BP produced the strongest protective effect from having a non-zero CAC score, 0.37 (95% CI 0.25-.57), followed by total cholesterol <200 mg/dL, 0.69 (95% CI 0.44-.90), and blood glucose <100 mg/dL, 0.69 (95% CI 0.47-.90).
Author Disclosures: A. Mehta: None.
- © 2017 by American Heart Association, Inc.