Abstract P362: Significant Positive Association Between Alcohol Consumption and Advanced Aortic Calcification in an International Multiethnic Cohort of 1335 Men Aged 40-49 Years: The ERA JUMP Study
Introduction: Aortic calcification (AC) is a less widely used measure of atherosclerosis, has been linked to cardiovascular (CV) morbidity and mortality. A J-shaped association of alcohol consumption with CHD has been consistently reported in epidemiological studies. However, scanty literature is available describing the association of alcohol consumption and AC.
Hypothesis: We hypothesized that alcohol consumption has a J-shaped association with advanced AC.
Method: ERA JUMP is a population-based study of subclinical atherosclerosis in 1335 men aged 40-49 years without CVD (310 European American, 107 African American, 303 Japanese American, 313 Japanese in Japan and 308 Korean in South Korea). Participants were examined for AC, alcohol consumption, CV risk and other factors in 2002-07 with rigorous standardization. AC was assessed by electron-beam CT and quantified using the Agatston method. Advanced AC was defined as Agatston calcium score ≥300. Alcohol consumption was categorized into four groups: 0 (non-drinkers), <1 (light drinkers), > 1 to < 3 (moderate drinkers) and >3 drinks per day (heavy drinkers) (1 drink=12.5 grams of ethanol). Multivariable logistic regression was used to assess the relationship between AC with alcohol consumption adjusting for age, race, CV risk and other factors.
Results: Among 1299 studied participants, after excluding participants with missing values for AC (n=36), 70.3% (913 of 1299) were current drinkers and 10.9% (142 of 1299) had advanced AC. Prevalence of advanced AC among non, light, moderate, and heavy drinkers was 7.25% (28 of 386), 10.89% (43 of 395), 9.06% (28 of 309), and 20.57% (43 of 209) respectively. Alcohol consumption had a positive association with advanced AC with a significant cubic trend (p<0.01). There was no significant interaction on advanced AC between race and alcohol consumption.
Conclusion: A significant positive association between alcohol consumption and advanced AC was observed in this cross-sectional study of an international multi-ethnic cohort.
Author Disclosures: H. Mahajan: None. J. Guo: None. S. Shangguan: None. B. Willcox: None. K. Miura: None. T. Okamura: None. A. Fujiyoshi: None. J. Choo: None. R. Evans: None. E. Barinas-Mitchell: None. L. Kuller: None. C. Shin: None. K. Masaki: None. H. Ueshima: None. A. Sekikawa: None.
- © 2017 by American Heart Association, Inc.