Abstract P361: Significant Inverse Association of Blood Levels of Marine Omega-3 Fatty Acids With Aortic Calcification in an International Multi-ethnic Cohort of 1335 Men Aged 40-49 Years: The ERA JUMP Study
Introduction: Aortic calcification (AC) is an independent predictor of future cardiovascular (CV) events. Marine omega-3 fatty acids (OM3) are reported to have anti-atherogenic properties.
Hypothesis: We hypothesized that blood levels of OM3 have a significant inverse association with AC.
Methods: ERA JUMP is a population-based study of subclinical atherosclerosis in 1335 men aged 40-49 without CVD (310 European American, 107 African American, 303 Japanese American, 313 Japanese in Japan and 308 Korean in South Korea). Participants were examined for AC, blood levels of OM3, CV risk and other factors in 2002-07 with rigorous standardization. AC was assessed by electron-beam CT and quantified using the Agatston method. OM3 were measured using gas chromatography, expressed as the percentage of total fatty acids and defined as the sum of eicosapentaenoic, docosapentaenoic and docosahexaenoic acids. After excluding missing data for AC (n=36), OM3 (n=8) and heavy drinkers (ethanol >69 g/day) (n=73), our final analytic sample was 1218. The association of the presence of AC with OM3 was analyzed using logistic regression adjusting for age, race, CV risk and other factors. We also performed Tobit regression and ordinal logistic regression to assess the relation between AC score (ACS) and OM3.
Results: Mean [standard deviation (SD)] of age, LDL-C, and pack-years of smoking were 45.2 (2.8) years, 127 (35) mg/dl and 9.5 (13.6), respectively. Prevalence (%) of hypertension and diabetes was 22.4 and 8.0, respectively. Mean (SD) of OM3 was 6.1 (3.1) (%) and 58.1% had ACS>0. In a fully adjusted model with stepwise backward elimination, odds of ACS>0 was reduced by 10% with one SD increase in OM3 level (p <0.001). Results of Tobit regression and ordinal logistic regression suggest a statistically significant lower ACS for every SD increase in OM3 level. There was no significant interaction on AC between race and OM3.
Conclusions: This cross-sectional study showed a significant inverse association of OM3 with AC in an international multi-ethnic cohort.
Author Disclosures: H.D. Mahajan: None. J. Guo: None. S. Shangguan: None. B. Willcox: None. K. Miura: None. A. Fujiyoshi: None. A. Kadota: None. J. Choo: None. R. Evans: None. E. Barinas-Mitchell: None. L. Kuller: None. C. Shin: None. K. Masaki: None. H. Ueshima: None. A. Sekikawa: None.
- © 2017 by American Heart Association, Inc.